Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2009 Jan 9;58(4):820–828. doi: 10.2337/db08-0551

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2009 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

PMC Copyright notice

FIG. 3. — Progressive insulin resistance and glucose intolerance in inducible liver-specific insulin receptor knockout (iLIRKO) mice. A: Insulin tolerance tests were performed on 2-, 4-, 6-, and 12-month-old male control (○) and iLIRKO (●) mice. Fed animals were injected intraperitoneally with 1 unit/kg body wt of human regular insulin. Blood glucose was measured immediately before injection and 15, 30, and 60 min after the injection. Results expressed as percentage of initial blood glucose concentration are means ± SEM (n = 10–20). B: Glucose tolerance tests were performed on 2-, 4-, 6-, and 12-month old control (○) and iLIRKO (●) mice that had been fasted for 16 h. Animals were injected intraperitoneally with 2 g/kg body wt of glucose. Blood glucose was measured immediately before injection and 30, 60, 90, and 120 min after the injection. Results are expressed as mean blood glucose concentration ± SEM; n = 10–20 of each genotype. **P < 0.005; *P < 0.05; iLIRKO versus control.