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. 2009 Jan 23;58(4):1007–1017. doi: 10.2337/db08-1215

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© 2009 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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FIG. 2. — Mapping of type 1 diabetes and type 1 diabetes subphenotypes in the F2 cohort along chromosomes 1–20. The Y-axis indicates the LOD score and the X-axis the chromosome number and genetic position. Horizontal lines represent the thresholds for suggestive (dotted line) and significant (dashed dotted line) linkage. From the top to bottom are shown the results of linkage analyses for type 1 diabetes, severity of islet infiltration by inflammatory cells, degree of islet integrity, and age of type 1 diabetes onset. Unless otherwise stated in the figure, all linkage analyses were based on interval mapping.