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. 2009 Jan 23;58(4):1007–1017. doi: 10.2337/db08-1215

TABLE 1.

Peak markers at each locus linked to type 1 diabetes and related traits

Chromosome Marker Position
 Trait Dataset D/ND/W Genotype and phenotype distribution
 LOD score R2
AA AB BB
cM Mb n/D:ND Mean ± SD % type 1 diabetes n/D:ND Mean ± SD % type 1 diabetes n/D:ND Mean ± SD % type 1 diabetes
1 D1Rat159 123.8 198.8 Cellular infiltration D 35 1.30 ± 0.63 55 1.45 ± 0.85 14 1.81 ± 1.00 2.93 12.73
1 D1Rat159 123.8 198.8 Islet integrity D 35 1.21 ± 0.83 55 1.51 ± 0.88 14 1.78 ± 0.81 2.34 10.28
1 D1Wox23 132.4 212.1 Islet integrity W 98 2.44 ± 0.89 219 2.57 ± 0.78 128 2.82 ± 0.50 4.19 3.66
1 D1Wox23 132.4 212.1 Type 1 diabetes W 36:98 26.9% 56:219 20.4% 11:128 7.9% 4.18 3.73
1 D1Rat76 153.3 230.4 Cellular infiltration ND 101 0.41 ± 0.64 221 0.58 ± 0.76 123 0.56 ± 0.74 2.61 2.78
2 D2Arb7 41.7 57.2 Islet integrity D 21 1.30 ± 0.50 49 1.10 ± 0.43 28 0.84 ± 0.41 2.82 13.20
2 D2Rat180 73.3 121.2 AOO D 19 126 ± 19.9 24 121 ± 22.6 31 107 ± 21.1 2.36 10.37
2 D2Rat180 73.3 121.2 Islet integrity W 129 2.75 ± 0.59 213 2.59 ± 0.77 104 2.47 ± 0.88 2.55 2.66
2 D2Got121 92.6 193.8 Islet integrity W 119 2.75 ± 0.57 222 2.61 ± 0.77 102 2.43 ± 0.87 2.74 2.20
2 D2Arb16 94.4 198.3 Type 1 diabetes W 11:121 8.3% 61:221 21.6% 32:101 24.1% 2.90 2.38
2 D2Rat88 116.1 222.3 AOO D 18 128 ± 21.3 55 119 ± 23.0 31 110 ± 20.8 2.98 13.92
2 D2Rat88 116.1 222.3 Cellular infiltration ND 119 0.58 ± 0.74 223 0.51 ± 0.74 104 0.54 ± 0.70 1.88 2.11
3 D3Rat7 112.5 145.6 Islet integrity W 158 2.42 ± 0.89 259 2.66 ± 0.69 124 2.69 ± 0.72 2.89 2.44
3 D3Rat7 112.5 145.6 Type 1 diabetes W 45:113 28.5% 41:218 15.8% 18:106 14.5% 2.68 2.21
6 D6Rat88 70.3 100.2 Type 1 diabetes W 13:117 10% 45:217 17.2% 45:102 30.6% 5.21 4.48
6 D6Rat81 76.3 112.0 Islet integrity W 107 2.78 ± 0.54 238 2.64 ± 0.72 100 2.38 ± 0.93 4.55 3.91
6 D6Rat94 94.1 131.5 Cellular infiltration ND 120 0.42 ± 0.66 227 0.52 ± 0.77 94 0.71 ± 0.72 2.04 2.08
6 D6Rat152 98.0 142.5 Cellular infiltration W 118 0.53 ± 0.75 236 0.67 ± 0.82 92 1.06 ± 0.88 6.78 5.35
6 D6Rat152 98.0 142.5 Islet integrity W 118 2.81 ± 0.52 236 2.66 ± 0.72 92 2.30 ± 0.94 7.54 5.93
6 D6Rat1 98.4 144.2 Type 1 diabetes W 8:120 6.3% 50:234 17.6% 46:92 33.3% 7.66 6.32
7 D7Rat30 20.7 30.3 Cellular infiltration D 26 2.06 ± 0.83 56 1.56 ± 0.62 15 1.36 ± 0.31 3.00 16.78
7 D7Wox48 97.5 129.5 AOO D 30 121 ± 22.9 52 121 ± 21.8 22 103 ± 20.0 2.71 15.37
8 D8Rat20 69.2 94.9 Islet integrity D 23 1.24 ± 0.38 44 1.15 ± 0.48 31 0.83 ± 0.42 3.75 18.23
8 D8Rat65 91.3 109.9 Cellular infiltration D 18 2.12 ± 0.72 51 1.66 ± 0.64 27 1.42 ± 0.63 2.63 12.54
12 D12Rat28 20.3 16.3 Cellular infiltration ND 96 0.78 ± 0.86 223 0.53 ± 0.72 122 0.37 ± 0.59 3.65 3.69
12 D12Rat28 20.3 16.3 Cellular infiltration W 96 1.03 ± 0.94 223 0.73 ± 0.81 122 0.47 ± 0.71 6.57 5.19
12 D12Rat28 20.3 16.3 Islet integrity W 96 2.41 ± 0.87 223 2.59 ± 0.77 122 2.81 ± 0.54 4.56 3.87
12 D12Rat28 20.3 16.3 Type 1 diabetes W 36:96 27.3% 58:223 20.6% 10:122 7.6% 3.82 3.14
14 D14Rat1 3.4 4.9 Islet integrity W 127 2.75 ± 0.62 227 2.62 ± 0.76 92 2.40 ± 0.86 3.74 3.30
14 D14Rat1 3.4 4.9 Type 1 diabetes W 14:127 9.9% 51:227 18.3% 39:92 29.8% 4.70 4.13
14 D14Rat42 8.8 14.3 Cellular infiltration W 114 0.60 ± 0.78 225 0.68 ± 0.83 86 0.99 ± 0.92 3.79 3.03
17 D17Rat11 19.9 30.9 Islet integrity W 118 2.70 ± 0.66 229 2.63 ± 0.74 93 2.43 ± 0.89 3.28 3.28
17 D17Rat11 19.9 30.9 Type 1 diabetes W 20:138 14.5% 51:280 18.2% 33:93 26.2% 1.98 1.95
18 D18Rat116 16.3 40.6 AOO D 30 107 ± 17.3 50 120 ± 23.0 18 128 ± 24.0 2.79 12.85

For each microsatellite marker, both the genetic (cM) and physical positions (Mb) are shown, and the trait to which linkage was found is indicated. Three different datasets were used: D, diabetic animals only; ND, nondiabetic animals only; W, whole cohort. The distribution of genotypes and phenotypes for each of these datasets is indicated as follows. For the genotypes: AA, ACI.BB1u.lyp homozygous, AB, heterozygous, and BB, BBDP homozygous. For each genotype, the first column indicates the number of animals, except for the type 1 diabetes trait for which the number of diabetic and nondiabetic (D:ND) animals is given. The second column shows the mean value for each trait ± SD, except for type 1 diabetes, for which the cumulative incidence is given as a percentage. The final two columns show the LOD score reached and the proportion of trait variance (R2) accounted for by each locus.