TABLE 2.
Haplotypes
| Haplotype | Frequency | Control subjects | Case subjects | χ2 | P | Odds ratio (95% CI) |
|---|---|---|---|---|---|---|
| Two-SNP haplotypes | ||||||
| AG | 0.829 | 0.799 | 0.857 | 9.0 | 0.0027 | 1.51 (1.15–1.99) |
| AA | 0.108 | 0.124 | 0.091 | 4.2 | 0.0404 | 0.70 (0.51–0.98) |
| TG | 0.063 | 0.077 | 0.051 | 4.1 | 0.0431 | 0.64 (0.42–0.98) |
| Four-SNP haplotypes | ||||||
| GAGG | 0.432 | 0.428 | 0.436 | 0.10 | 0.7495 | 1.03 (0.84–1.27) |
| GTAG | 0.393 | 0.386 | 0.398 | 0.23 | 0.6323 | 1.05 (0.85–1.30) |
| ATAG | 0.139 | 0.141 | 0.138 | 0.04 | 0.8336 | 0.97 (0.72–1.30) |
| GAGA | 0.023 | 0.035 | 0.012 | 8.26 | 0.0041 | 0.34 (0.16–0.73) |
| GTGA | 0.013 | 0.010 | 0.016 | 0.09 | 0.3259 | 1.67 (0.65–4.26) |
Association of DM-ESRD with two-SNP haplotypes consisting of the two nominally significant SNPs rs12763743 and rs3897983. The AG haplotype is referred to as the two-SNP risk haplotype, and the AA and TG haplotypes are referred to as the two-SNP protective haplotypes. Association of DM-ESRD with four-SNP haplotypes consisting of rs4918972, rs10748648, rs1342790, and rs3793744. The GAGA haplotype is referred to as the four-SNP protective haplotype.