Table 1. Platelet aggregometry analytic metrics.
| 1 LRP8+/+ | 1 LRP8+/- | 1 LRP8-/- | 2 Overall p-value | 3 Dunnett's p-value | |
|---|---|---|---|---|---|
| ADP (n=5) | |||||
| 4 Slope | 1.45 (0.25) | 0.85 (0.23) | 0.85 (0.21) | 0.016 | <0.05 |
| 5% Aggregation | 47.40 (8.70) | 33.20 (10.07) | 31.40 (7.41) | 0.022 | <0.05 |
| Thrombin (n=4) | |||||
| 4 Slope | 1.18 (0.48) | 0.33 (0.15) | 0.24 (0.14) | 0.033 | <0.05 |
| 5% Aggregation | 42.50 (17.70) | 25.25 (16.33) | 20.75 (13.95) | 0.013 | <0.05 |
1
Values expressed as mean (SEM)
2
P-values generated using a repeated measures ANOVA
3
P-values for LRP8+/- and LRP8-/- vs. LRP8+/+ by Dunnett's post-test.
4
Absolute value of the slope of the results between minutes 1-2 of aggregation calculated by linear regression
5
Maximum aggregation in response to agonist