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. Author manuscript; available in PMC: 2010 Jan 1.
Published in final edited form as: Peptides. 2008 Jul 10;30(1):67–75. doi: 10.1016/j.peptides.2008.06.029

Figure 2.

Figure 2

LH discharges induced precociously in agonadal juvenile male monkeys (20-24 months of age) by an intermittent iv infusion of GnRH that mimics a castrate adult hypophysiotropic drive to the gonadotrophs (open arrows on Day 1) and by brief infusions of h-kisspeptin-10 every h (closed arrows) initiated on Day 1 immediately following termination of GnRH priming and maintained for 48 h in a crossover design (kisspeptin-10, closed data points; vehicle, open data points). LH responses are shown for the first three kisspeptin-10 or vehicle pulses on Day 1, three such pulses on Day 2 and the last two pulses on Day 3. GnRH priming (open arrows) was reinitiated after completion of kisspeptin-10 or vehicle administration on Day 3. Reprinted with permission from [20].