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. 2009 Feb 24;100(6):932–940. doi: 10.1038/sj.bjc.6604938

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Copyright © 2009 Cancer Research UK

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Effect of P529, RT, and P529+RT and the combination on p-Akt, total Akt, Bcl-2, and Bax. Ionising radiation causes a >10-fold increase in p-Akt levels. However, when P529 is added to the treatment, p-Akt levels are lower than those observed in untreated cells. Total Akt levels are also increased in RT-treated cells, but levels return to normal when the drug is added. Bcl-2 decreases as a consequence of P529, RT, and combination treatment, whereas Bax increases in RT- and RT+P529-treated cells. The densitometric analysis shows that the Bcl-2/Bax ratio is reduced in RT and RT+P529 cells. The Y-axis represents fold changes with respect to control.