Figure 1.

(a) Cryomicrographs of poliovirus particles complexed with (Top) and without (Bottom) sPvr. Bar = 300 Å. Image reconstructions are shown of virion + sPvr [in stereo (b)] and, for comparison, of the virion (c) (from ref. 9). The two reconstructions were overlaid in d with the respective contour levels adjusted to clarify the interaction of sPvr with the virion. Bar = 100 Å. (e) Two views of a single sPvr molecule extracted from the difference map. Domain boundaries are marked. Bar = 25 Å.