FIGURE 1.

Structures of siRNA and conjugates used in this study. (A) Schematic presentation of names and sequences and modifications of siRNAs used here. (B) Structure of covalent linkage between siLAM and the bacterial peptide TQIENLKEKG. (p) Passenger strand; (g) guide strand; (dT) deoxyribothymidine; (s in PS-ON depicted in panel A) internucleotide phosphorothioate; one-letter code for amino acids indicated in bold; the two consecutive underlined C residues at positions 10 and 11 of siLAM-mut and siLAM-mut-pTOX indicate mutations of the parental guide strand; (TOX) TQIENLKEKG; (PTS1) peroxisomal targeting signal 1, SKL.