Figure 6. Model of the HD-PTP catalytic domain.

A) The HD-PTP homology model was based on the structure of a PTP1B substrate complex (pdb-code: 1g1h). HD-PTP residues are labeled in black and PTP1B residues in grey, respectively. Shown are conserved residues known to play key roles in PTP substrate recognition and catalysis that are altered in HD-PTP. B–C) Surface representations of the PTP1B active site associated with two phosphate residues (B) and prediction of the HD-PTP protein associated with one phosphate (C).