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The inhibition of NPM-ALK abrogated the ATIC activity in ALCL cells. The enzymatic activity of ATIC, G6PD, and ODC was measured in ALK+ (TS, SU-DHL1, JB-6) and ALK− (Mac-1) lymphoblastoid cell lines after treatment with a specific ALK inhibitor, as described in “Measurement of AICAR-FT/IMP-CHase activity.”
