Table 1.
Relative risk of heterosexual transmission of HIV between serodiscordant couples per 0.3, 0.5, and 1.0 log10 increment of plasma HIV RNA concentration.
| Risk ratio per log10 Δ HIV RNA | ||||||
|---|---|---|---|---|---|---|
| Reference | No. of discordant couples | No. of events | Viral assay | 0.3 | 0.5 | 1.0 |
| Quinn et al. [23]a | 415 | 90 | RT-PCR | 1.31 (1.20, 1.42) | 1.56 (1.36, 1.80) | 2.45 (1.85, 3.26) |
| Fideli et al. [24]b | 1022 | |||||
| Female-to-Male | 43 | RT-PCR | 1.3 (1.1, 1.5) | 1.6 (1.2, 2.0) | 2.5 (1.5, 4.0) | |
| Male-to-Female | 66 | RT-PCR | 1.2 (1.0, 1.4) | 1.3 (1.1, 1.7) | 1.8 (1.2, 2.8) | |
| Hisada et al. [25]a | 299 | 9 | bDNA | 1.14 (0.97, 1.36) | 1.19 (0.98, 1.20) | 1.31 (0.94, 1.84) |
| Tovanabutra et al. [26]c | 493 | 218 | RT-PCR | 1.19 (1.09, 1.31) | 1.34 (1.15, 1.57) | 1.81 (1.33, 2.48) |
|
| ||||||
| Weighted mean | 1.2 (1.1, 1.4) | 1.4 (1.2, 1.7) | 2.0 (1.4, 2.8) | |||
bDNA, branched DNA signal-amplification assay (Chiron, Emeryville, CA, U.S.A.); RT-PCR, reverse transcriptase – polymerase chain reaction (Amplicor HIV monitor test, Roche Diagnostic Systems, Inc., Branchburg, NJ, U.S.A.).
a
History of heterosexual couple contacts based on self-report.
b
Viruses sequenced to exclude non-transmitting couples from analysis.
c
Cross-sectional study that did not measure incident infections nor exclude individuals with other HIV infection risk factors for transmission.