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Dose dependent mutagenicity of 5MC-1,2-diol was determined in hCYP1B1 and hCYP1A1 cell lines. Cells were exposed to the indicated concentrations of 5MC-1,2-diol for 48 hours and mutagenicity assays were performed as described in Materials and Methods. Symbols: closed circles, V79MZh1B1 cell line; open triangles, V79MZh1A1 cell line. Each value represents the mean ± SD of three independent assays.
* significantly different from V79MZh1A1 value (p < .05).
