Table 3.
Hemodynamic responses (mean ± SD) during 5-hr exposure to FA or CAPs in eight dogs treated with prazosin, an α-adrenergic antagonist.
| Parameter | FAa (n = 15 days) | CAPsa (n = 16 days) | Crude differenceb | Adjusted differencec | p-Valuec |
|---|---|---|---|---|---|
| Systolic pressure (mmHg) | 119.8 ± 22.8 | 119.1 ± 20.3 | −0.7 | 2.8 ± 2.8 | 0.33 |
| Diastolic pressure (mmHg) | 81.9 ± 18.1 | 79.6 ± 14.8 | −2.3 | 1.3 ± 1.5 | 0.40 |
| Mean pressure (mmHg) | 94.4 ± 18.4 | 92.8 ± 15.2 | −1.6 | 1.8 ± 1.9 | 0.34 |
| Pulse pressure (mmHg) | 38.0 ± 15.4 | 39.5 ± 15.5 | 1.5 | 1.4 ± 1.2 | 0.26 |
| Heart rate (bpm) | 98.4 ± 13.4 | 96.9 ± 10.8 | −1.5 | −1.8 ± 1.0 | 0.06 |
| Rate–pressure product (bpm × mmHg) | 11,779 ± 2,686 | 11,548 ± 2,361 | −231 | 8 ± 198 | 0.97 |
a
Mean ± SD of 5-min average data.
b
Estimated as difference between mean levels during FA and CAPs exposures.
c
Estimated effect of CAPs exposure ± SE from a linear mixed model controlling for dog as a fixed effect, week-within -dog as a random effect, and first-order autoregressive serially correlated errors over time within exposure group.