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. 2008 Oct 16;117(3):367–372. doi: 10.1289/ehp.11608

Figure 1.

Figure 1

Path diagram for an SEM linking mercury exposure to adverse effects, with adjustment for confounders. The estimated true exposure (Hg) is modeled as a latent parameter based on mercury concentrations in toenail (N-Hg), blood (B-Hg), and hair sample taken 7 years ago (H-Hg7). Three latent effect parameters, HRV, CVF, and latencies of BAEP, are expressed by a series of heart variability, cardiovascular, and BAEP (peaks III and V at both 20 and 40 Hz) test results, respectively. HRV, CVF, and BAEP may be correlated (indicated by double-headed arrows), and potential confounders are allowed to be associated with both the latent exposure variables and the latent effect variables.