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. 2008 Oct 23;117(3):379–386. doi: 10.1289/ehp.11865

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The proteasome-inhibitory and cell-death–inducing activities of organotins in MDA-MB-231 cells. Try, trypsin. (A) Proteasomal CT-like activity measured in intact MDA-MB-231 cells treated with the solvent methanol (Sol), inorganic Sn salt (SnCl₄), or organotins (butyltins and phenyltins) at 10 μmol/L for 3 hr, followed by 1 hr additional incubation with 40 _mol/L of Z-CGL-AMC. (B) Western blot assay of ubiquitinated (Ub-)proteins, Ub-IκB-α, PARP, and Bax proteins in extracts from MDA-MB-231 cells treated with 10 μmol/L of organotins, SnCl₄, or control for 4 hr. (C) Preferential inhibition of CT-like activity of cellular proteasome by TPT. Data are mean ± SD of three experiments.

*p < 0.05. **p < 0.01.