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. 2008 Oct 23;117(3):379–386. doi: 10.1289/ehp.11865

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Dose effects of TPT and TBT on proteasome inhibition and cell death induction in MDA-MB-231 cells. Abbreviations: PI, propidium idodide; TdT FITC, terminal deoxynucleotidyl transferase fluorescein isothiocyanate. (A) Proteasomal CT-like activity measured in MDA-MB-231 cells exposed to either methanol (Sol), SnCl₄ at 5 μmol/L, TPT, or TBT at the indicated concentrations for 6 hr (data are mean ± SD of three experiments). (B) Western blot assays of ubiquitinated proteins, ubiquitinated IκB-α (Ub-IκB-α), PARP, and Bax proteins levels in cell extracts. (C) Morphologic changes (100× magnifications; scale bar, 150 μm. (D) TUNEL assay.

*p < 0.05. ** p < 0.01.