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Pathology observed for > 10% of ToxRefDB chemicals in chronic/cancer rat and mouse studies.
| Target organ | Effect | Percent observed |
|---|---|---|
| Rat | ||
| Liver | Hypertrophy | 25 |
| Kidney | Nephropathy | 14 |
| Liver | Vacuolization | 12 |
| Thyroid | Adenoma | 11 |
| Thyroid | Hyperplasia | 11 |
| Mouse | ||
| Liver | Hypertrophy | 25 |
| Liver | Adenoma | 21 |
| Liver | Necrosis | 16 |
| Liver | Adenoma/carcinoma combined | 14 |
| Liver | Pigmentation | 14 |
| Liver | Carcinoma | 12 |
