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. 2008 Sep 12;117(3):426–435. doi: 10.1289/ehp.11771

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Developmental A1254 exposure at 1 mg but not 6 mg/kg/day impairs performance in the Morris water maze. (A) Escape latency as a function of trial. (B ) Percentage of animals that reached criterion (escape latency ≤ 10 sec) during the 7-day training period. (C) Probe tests conducted on day 4. Dotted line indicates predicted time spent in the training quadrant by chance alone. (D) Performance in visual cue test and swimming speed. (E) Representative swim paths from probe tests on day 4. Data are presented as mean ± SEM.

*p< 0.05, **p < 0.01 ( A, repeated measures ANOVA; B, Fisher’s exact test; C and D, ANOVA; Newman-Keuls post hoc).