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. 2008 Sep 12;117(3):426–435. doi: 10.1289/ehp.11771

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Developmental A1254 exposure alters RyR expression in the cerebellum. (A) Representative blot of cerebellar membrane samples from P21 and maze-trained P31 rats probed with RyR antibodies. (B) Densitometric analyses of RyR1 and RyR2 expression in the cerebellum at P21. Band densities of samples from A1254-treated animals are plotted as percentage of mean control band densities. (C) Cerebellar expression of RyR1 and RyR2 as a function of age in nonmaze-trained animals. Data are presented as percent change in mean pixel density from P21 to P31 within each treatment group. (D) Effects of maze training and developmental A1254 exposure on RyR1 and RyR2 expression in the cerebellum. Data are presented as mean ± SEM (n ≥ 4). Asterisks associated with individual bars indicate statistically significant differences between P21 and maze-trained P31 rats within a group; asterisks above horizontal lines indicate statistically significant difference between groups.

*p< 0.05, **p < 0.01, #p < 0.001 (ANOVA; Bonferroni post hoc).