Skip to main content
. Author manuscript; available in PMC: 2010 Jan 1.
Published in final edited form as: Mol Cell Neurosci. 2008 Sep 18;40(1):39–49. doi: 10.1016/j.mcn.2008.08.011

Fig. 10. SK2 expression during early synaptic refinement periods and in the adult cochlea in mice lacking the nAChR α9 subunit.

Fig. 10

A: SK2 immunostaining of P7 wild type mice demonstrates no detectable expression in the OHC region. Inner and outer pillar cells (IPC, OPC) are immunopositive, but no distinct localization is apparent. B: In α9-/- mice, distinct localization of SK2 along the lateral walls of OHCs can be observed at P7 as indicated by the line segments. Scale bar in A applies also to B. C: At higher magnification, the distinct localization of SK2 along the lateral walls of the OHC is more readily apparent. A few of the SK2 puncta are indicated by arrows. The nucleus of one OHC is indicated by an asterisk for purposes of orientation. D: In the mature α9-/- cochlea, SK2 puncta (red, one of which is indicated by an arrow) are lost from the lateral walls, and have collapsed to take up a position apposed to the incoming OC terminals, stained by synaptophysin antibodies (green). The lateral olivocochlear system (LOCS) is indicated in the inner hair cell region for orientation purposes.