. 2008 Aug 27;66(5):695–705. doi: 10.1111/j.1365-2125.2008.03261.x

Table 4.

List of cardiovascular major anomalies

Paroxetine (n = 8)	Additional medications	Fluoxetine (n = 9)	Additional medications	Control (n = 8)
ASD, VSD and coarctation of aorta (operated at 16 days)	Oxazepam, diclofenac inj. 8th week, nifedipine, atenolol 3rd trim.^a	VSD and TGA^†^b	None	RBBB and moderate TR (present at 2 years, needs catheterization)^a
Unspecified CHD (operated at 2 months)	Oxazepam, dipyrone, ibuprofen 7th week, penicillin V-K^c	Small muscular VSD (diagnosed at 6 months, closed by 1 year)^*^a	Enoxaparin throughout pregnancy	VSD (closed by 11 months)^c
Hypoplastic left heart, 2 VSDs, large ASD and small mitral valve (died at 1 year)^*	Clonazepam from 22nd week^a	Pulmonary valve stenosis (perinatally diagnosed)^a	None	Small muscular VSD (prenatally diagnosed, present at 3 months)^a
Left mild pulmonary artery stenosis, PFO and mild left ventricular distension	None^a	Unspecified CHD^a	Carbamazepine, clonazepam, erythromycin, ethinylestradiol + levonorgestrel	PDA (diagnosed on 3rd day, present at 1 month)^a
Pulmonary valve stenosis (perinatally diagnosed)	None^a	Mild pulmonary artery stenosis (perinatally diagnosed, present at 4 years)^*^d	Clonazepam	PR and VSD (closed at 7 months)^a
Clinically significant TR	Diazepam until week 7, dipyrone^a	ASD (diagnosed before 5 months)^b	None	VSD and ASD^a
Small VSD and PFO (perinatally diagnosed)	Clotrimazole 36th week^a	ASD (needs catheterization)^a	None	Small PDA (perinatally diagnosed, closed), pulmonary hypertension^c
Pulmonary artery stenosis, PFO and pes calcaneus (perinatally diagnosed)	Alcohol abuse 70 g day⁻¹ until the 12th week, smoking cannabis 1 g day⁻¹, occasionally heroin abuse and opipramol, promethazine, clobutinol and acetylcysteine in 1st trim.^c	Critical aortic valve stenosis with dysplastic bicuspid aortic valve (perinatally diagnosed, dilated)^c	None	ASD (perinatally diagnosed)^a
		VSD (perinatally diagnosed, closed)^a	Metronidazole (vaginally)

Exposure not during the first trimester of pregnancy.

^†

Electively terminated pregnancy. ASD, atrial septal defect; CHD, congenital heart defect; PDA, patent ductus arteriosus; PFO, patent foramen ovale; PR, pulmonic regurgitation; RBBB, right bundle branch block; TGA, transposition of great arteries; TR, tricuspid regurgitation; VSD, ventricular septal defect.

Smoking status none

Smoking status <10 cig day⁻¹

Smoking status ≥10 cig day⁻¹

Smoking status unknown