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. 2008 Sep 24;66(5):728–731. doi: 10.1111/j.1365-2125.2008.03279.x

Table 2.

Symptoms after toxic ingestion of caffeine [5, 8, 10]

Organ (system) Symptoms
Central nervous system Fear, hallucinations, restlessness, insomnia, coma, tremor, seizures, headache, photophobia
Cardiovascular system Arrhythmias (most frequently atrial or ventricular tachycardia), hypertension (or in severe cases hypotension), myocardial infarction, ischaemic stroke, collapse
Respiratory system Hyperventilation, acute lung injury
Gastrointestinal tract Nausea, vomiting
Kidneys Polyuric state, acute renal failure
Muscles Paralysis, rhabdomyolysis
Haematology Leucocytosis
Metabolism Hyperglycaemia, lipolysis, ketogenesis
Acid-base balance Lactic acidosis caused by hyperadrenergic state or by seizures or hypotension; respiratory alkalosis
Electrolytes Hypokalaemia, hyponatraemia