TABLE 1.

Increased colony formation of JAB1-Tg hematopoietic progenitors in vitro

Results are the means ± S.D. of three independent experiments. E, erythroid lineage; GM, granulocyte/macrophage lineage; Mix, mixture of all lineages; BM, bone marrow; Sp, spleen; PB, peripheral blood.

JAB1 genotype	Source of cells	Colony number/10,000 cells
				Without TAP-JAB1			With TAP-JAB1
		E	GM	Mix	E	GM	Mix
+/+	BM	6.33 ± 1.86	58.2 ± 13.3	1.00 ± 0.63	16.3 ± 13.2	122 ± 73.7	6.50 ± 5.39
+/-	BM	2.50 ± 1.00	24.0 ± 8.70	0.75 ± 0.96	3.75 ± 1.71	67.0 ± 10.0	5.75 ± 0.96
+/+	BM 2nda	6.00 ± 1.41	17.5 ± 0.71	0	10.5 ± 4.95	36.5 ± 2.12	1.00 ± 1.41
+/+	BM 3rda	0	12.0 ± 5.66	0	0	120 ± 7.78	0
+/+	Sp	1.00 ± 0.89	1.67 ± 2.34	0.33 ± 0.82	3.17 ± 1.72	5.00 ± 2.97	0.83 ± 0.75
+/+	PB	0	0	0	2.00 ± 3.37	3.50 ± 3.70	0.50 ± 0.58

^aReplating for the second and third rounds.