FIGURE 4.

Stereo figure of the superposition of the three independent TAFI molecules with the attached sugars, sulfate, and malonate ions. The conformation of the three molecules is almost identical. The malonate molecule, bound in the active site is shown as a Corey, Pauling, Koltun model. The putative instability region is shown in gold. The bound sulfates are concentrated in three regions: a; the instability region, colored in gold; b, across the active site cleft toward the pro-domain, colored in magenta; and c, at the top of the pro-domain, colored in blue.