A and B, oral lipid tolerance test in rats. The study was
conducted as described under “Experimental Procedures.” The time
course (A) and area under the curve (AUC)(B) of the
initial 6 h of TAG detected in the serum was plotted. For each group,
n = 6. Data shown are means ± S.E. *, p < 0.05 as
compared with vehicle control. C, gastric emptying assay in rats. The
study was conducted as detailed under “Experimental Procedures.”
XP620 at 10 and 30 mg/kg did not affect gastric emptying, whereas 5 μg of
CCK-8 significantly reduced emptying of the test meal. For each group,
n = 10. Data shown are means ± S.E. **, p < 0.01
as compared with vehicle control. D, MTP in vitro assay.
Data shown are means ± S.D. of triplicate determinations.