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Potency of XP620 against various intestinal acyltransferases
|
Substrate
|
XP620 IC50
|
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
DGAT1
|
DGAT2
|
MGAT2
|
MGAT3
|
||||||||
| Human | Rat | Mouse | |||||||||
| nm | |||||||||||
| 1,2-DOG | 1499 ± 318 | 176 ± 40 | 123 ± 4 | >30,000 | NAa | NA | |||||
| 2-MOG | 16.6 ± 4.0 | 2.9 ± 0.5 | 2.7 ± 0.9 | >30,000 | >30,000 | >30,000 | |||||
| 1-Hexadecanol | 23.3 | 1.4 | |||||||||
NA, not available.
