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. 2008 Oct 31;283(44):30025–30033. doi: 10.1074/jbc.M803053200

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Copyright © 2008, The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 1. — DNA-PK is dispensable for PKB Ser-473 phosphorylation upon insulin and growth factor stimulation. After overnight fasting and insulin (ins) stimulation (1 unit/kg body weight) for 20 min, tissues from 3-month-old (WT) and DNA-PKcs^-/- (KO) mice were analyzed for PKB Ser-473 phosphorylation via immunoblotting with phospho-specific antibodies. A, skeletal muscle; B, liver; C, heart; D, adipose tissue. Wild-type and DNA-PKcs^-/- MEFs (KO) were stimulated with IGF-1 (50 ng/ml) (E) or serum (10%) (F) for various times, and PKB Ser-473 phosphorylation was analyzed by immunoblotting.