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Deletion of PKBα prevents spontaneous development of thymic tumors. A, incidence of thymic tumors from wild-type (WT), DNA-PKcs-/- (KO) analyzed between 3 and 7 months age and DNA-PKcs-/- PKBα-/- double knock-out (DKO) mice analyzed between 2 and 15 months age. B, PKB Ser-473, FoxO4 Ser-193, and FoxO3a Thr-32 phosphorylation in WT thymus, DNA-PKcs-/- tumor, and DNA-PKcs-/-PKBα-/- (DKO) thymi.
