Deletion of PKBα prevents spontaneous development of thymic
tumors. A, incidence of thymic tumors from wild-type
(WT), DNA-PKcs-/- (KO) analyzed between 3 and 7
months age and DNA-PKcs-/- PKBα-/- double
knock-out (DKO) mice analyzed between 2 and 15 months age.
B, PKB Ser-473, FoxO4 Ser-193, and FoxO3a Thr-32 phosphorylation in
WT thymus, DNA-PKcs-/- tumor, and
DNA-PKcs-/-PKBα-/- (DKO) thymi.