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. 2008 Oct 31;283(44):30025–30033. doi: 10.1074/jbc.M803053200

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Copyright © 2008, The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 6. — Deletion of PKBα improves survival of DNA-PKcs^-/- mice. Kaplan-Meier survival curves for wild-type (WT), DNA-PKcs^-/-, PKBα^-/-, and DNA-PKcs^-/-PKBα^-/- double knock-out (DKO) mice analyzed by LogRank analysis and the Holm-Sidak multiple comparisons procedure. The survival of DNA-PKcs^-/-PKBα^-/-DKO mice significantly increased compared with DNA-PKcs^-/- mice (p < 0.001). Mice that survived longer than 2 months were included in the analysis. Numbers of mice analyzed are as follows: WT 52; DNA-PKcs^-/- 21; PKBα^-/- 26; and DNA-PKcs^-/-PKBα^-/- (DKO) 13.