FIGURE 6.

Analysis of C1-resistant fragment. A–C, immunoblot analysis of PrP in two different samples from an MM2-T subject (lanes 1–2 versus lane 3, respectively) (A); white matter from an MM1 subject (B); and white matter from a CJD-negative case (C). The samples were either untreated or treated with PK at the indicated concentrations. All samples were digested with PNGase F. Membrane was probed by SAF60. The C1 fragment is indicated with an arrow. Approximate molecular masses are in kilodaltons.