Effects of MCT-1 and its human homologue hMCT-1 on the stimulation of
β-hexosaminidase release and chemotaxis on HL-60-derived
neutrophilic/granulocytic cells. The abilities of fMLF (circles),
MCT-1 (triangles), and hMCT-1 (squares) to induce
β-hexosaminidase release (closed symbols) are expressed as the
percentages of enzyme secretion induced by stimulation with 10
μm fMLF. Chemotactic activities (open symbols)
stimulated by fMLF (circles), MCT-1 (triangles), and hMCT-1
(squares) are expressed using the chemotaxis index, which indicates
the fold increase in the number of cells that migrated compared with the
number obtained with the vehicle. All data are expressed as mean ± S.E.
of six independent experiments.