FIGURE 5.

Effects of MCT-1 and its human homologue hMCT-1 on the stimulation of β-hexosaminidase release and chemotaxis on HL-60-derived neutrophilic/granulocytic cells. The abilities of fMLF (circles), MCT-1 (triangles), and hMCT-1 (squares) to induce β-hexosaminidase release (closed symbols) are expressed as the percentages of enzyme secretion induced by stimulation with 10 μm fMLF. Chemotactic activities (open symbols) stimulated by fMLF (circles), MCT-1 (triangles), and hMCT-1 (squares) are expressed using the chemotaxis index, which indicates the fold increase in the number of cells that migrated compared with the number obtained with the vehicle. All data are expressed as mean ± S.E. of six independent experiments.