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Model of E2F1-inducible changes in transcription factor occupancy of the GRP78/BIP promoter. In stressed cells, Sp proteins are in contact with the distal GC-box and GC motifs of the ERSE-N9 region in the GRP78/BIP promoter. Upon E2F1 activation, E2F1 binds to its putative sites within the GC sequence motifs, resulting in the displacement of transcription factor binding to these regions, thereby acting as a transcriptional repressor.
