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. 2008 Nov 28;283(48):33296–33303. doi: 10.1074/jbc.M804617200

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Copyright © 2008, The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 5. — Impaired C5/C5a production in PI3Kδ^-/- mice. At 2–4 h following OVA/anti-OVA (IC) and anti-OVA (Ab) challenge in PI3Kγ^-/- or PI3Kδ^-/- mice or their WT controls, lungs were lavaged and assayed for cellular C5 mRNA expression by real-time RT-PCR (A and B), and C5a-mediated C5aR-triggered chemotactic activity of BALF was determined by Transwell migration assays of neutrophils (PMN isolated from bone marrow of C57BL/6 and C5aR^-/- B6 mice) (C). Results are shown as the means ± S.E. (n = four to seven mice for each group). Significant differences were determined by Student's t test (^*, p < 0.05; ^**, p < 0.001). AU, arbitrary units; n.d., not determined.