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Death domain interactions inferred by analogy with the PID-Dosome core complex (25). The active Toll complex is comprised of a hexameric array having two dMyD88-Tube-Pelle heterotrimers (dMyD88 1-T1-P1 and dMyD88 2-T2-P2). The dMyD88-Tube interface is either Type I or Type II, whereas the Pelle-Pelle (P1-P2) and dMyD88-dMyD88 (dMyD88 1-dMyD88 2) interfaces are likely Type I. A Type III surface is generated at the geometric center where Tube-Tube (T1:T2) contacts are possible.
