TABLE 2.

Cathepsin S subsite specificities for cleavage sites

Favorable amino acids are marked +, less favorable are marked 0, and unfavorable are marked –. The ranking reflects the results shown in Fig. 1 and Table 1.

Side chain		P-2 position	P-1 position	P-1′ position	P-3′ position
Hydrophobic	Aromatic	+ (only Phe)	-	-	+
	Aliphatic	+ (not Ile)	-	+	+
	Methionine	+	+	-	+
	Proline	-	+	-	Not tested
Neutral	Amide	-	+	-	0
	Small	-	+	0	-
Basic		-	+	-	-
Acidic		-	-	-	-