Table 2.
Potential for direct AHR regulation of genes that play major roles in polarization of TH differentiation based on the presence of DRE sequences in their promoters.
| Genes involved in polarization of TH differentiation | DREs1 | Receptor Gene | DREs | Associated molecules | DREs |
|---|---|---|---|---|---|
| Ifng | Ifngr | 11 | Ifi472 | 6 | |
| Ifngr2 | 5 | Igtp3 | 7 | ||
| Tgfb1 | 10 | Tgfbi4 | 12 | ||
| Tgfb2 | 15 | Tgfbr2 | 12 | Tgfb1i15 | 10 |
| Tgfb3 | 5 | Tieg16 | 13 | ||
| Tbrg47 | 10 | ||||
| Tgif8 | 13 | ||||
| Il2 | 3 | Il2rb | 7 | ||
| Il2rg | 5 | ||||
| Il4 | 2 | Il4ra | 9 | ||
| Il6 | 6 | Il6st9 | |||
| Il10 | 3 | Il10ra | 4 | Iltifb10 | 4 |
| Il12a | 3 | IL12rb1 | 4 | IL12a | 3 |
| Il12b | 3 | IL12rb2 | 6 | IL12b | 3 |
| Il17 | 3 | 1l17r | 6 | ||
| Il17b | 3 | Il17rb | 3 | ||
| Il17d | 8 | 1l17c | 6 | ||
| 1l17rd | 7 | ||||
| Il17re | 6 | ||||
| Il21 | 4 | IL21r | 5 | ||
| Il23a | 5 | ||||
| IL27ra | 10 | ||||
| Gata3 | 10 | ||||
| Foxp3 | 5 | ||||
| Jak1 | 5 | ||||
| Jak2 | 9 | ||||
| Jak3 | 20 | ||||
| Stat1 | 9 | ||||
| Stat2 | 5 | ||||
| Stat3 | 5 | ||||
| Stat4 | 4 | ||||
| Stat5a | 9 | ||||
| Stat5b | 7 | ||||
| Stat6 | 12 | ||||
| Socs111 | 18 | ||||
| Socs2 | 8 | ||||
| Socs3 | 11 |
1
DRE expression from Table S1b, mouse DREs Sun et al. (14)
2
interferon gamma inducible protein
3
interferon gamma induced GTPase
4
transforming growth factor beta 1 induced
5
transforming growth factor, beta induced transcript 1
6
TGFB inducible early growth response 1
7
transforming growth factor beta regulated gene 4
8
TG interacting factor (TGFB-induced factor homeobox 1)
9
interleukin 6 signal transducer
10
interleukin 10-related T cell-derived inducible factor beta
11
Suppressor of cytokine signaling (Socs)