Table 1. Heterocycle Synthesis by Functionalization of the Linker, Metathesis, and Release (See Scheme 1 for the Definitions of R^F and R′^F).

^aMethod A: reactant (4 equiv), PPh₃ (4 equiv), DEAD (4 equiv), THF, rt then F-SPE. Method B: (i) Hoveyda−Grubbs second generation catalyst, CH₂Cl₂, reflux; (ii) P(CH₂OH)₃, Et₃N then silica; (iii) F-SPE. Method C: 3% TFA in CH₂Cl₂, rt then F-SPE. Method D: (i) NaH, THF, 0 °C; (ii) allyl bromide, rt; (iii) MeOH then F-SPE;

^bSee Scheme 1 for the definitions of R^F and R′^F.

^cUnless otherwise stated, isolated yield of product.

^dMass of product after F-SPE.

^ePurity (%) determined by HPLC after F-SPE.

^f10 equiv of the sulfonamide, PPh₃, and DEAD were used.

^gIn the presence of an ethylene atmosphere.

^hNot undertaken.