Table 2.
Cause-specific mortality versus baseline BMI in the ranges 15–25 kg/m2 and 25–50 kg/m2
|
15–25 kg/m2 |
25–50 kg/m2 |
|||
|---|---|---|---|---|
| Deaths | HR (95% CI) | Deaths | HR (95% CI) | |
| Ischaemic heart disease | 7461 | 1·22 (1·13–1·32) | 10 783 | 1·39 (1·34–1·44) |
| Stroke | 2964 | 0·92 (0·82–1·03) | 3164 | 1·39 (1·31–1·48) |
| Other vascular disease | 2648 | 0·84 (0·75–0·95) | 3396 | 1·47 (1·39–1·56) |
| Diabetes | 171 | 0·96 (0·59–1·55) | 393 | 2·16 (1·89–2·46) |
| Kidney disease (non-neoplastic) | 197 | 1·14 (0·74–1·77) | 217 | 1·59 (1·27–1·99) |
| Liver disease (non-neoplastic) | 489 | 0·69 (0·52–0·91) | 603 | 1·82 (1·59–2·09) |
| Lung cancer | 2959 | 0·71 (0·63–0·79) | 2040 | 0·98 (0·88–1·09) |
| Upper aerodigestive cancer | 685 | 0·49 (0·39–0·61) | 471 | 0·98 (0·79–1·20) |
| Other specified cancer | 6134 | 0·94 (0·87–1·02) | 6190 | 1·12 (1·06–1·18) |
| Respiratory disease* | 2426 | 0·31 (0·28–0·35) | 1344 | 1·20 (1·07–1·34) |
| Other specified disease | 2049 | 0·62 (0·54–0·71) | 1823 | 1·20 (1·10–1·31) |
| External cause | 2112 | 0·82 (0·71–0·95) | 1720 | 1·19 (1·08–1·32) |
| Unknown cause† | 4961 | 0·72 (0·66–0·79) | 5349 | 1·22 (1·16–1·28) |
| All causes | 35 256 | 0·79 (0·77–0·82) | 37 493 | 1·29 (1·27–1·32) |
Hazard ratio per 5 kg/m2 higher BMI (HR). HR less than 1 if BMI inversely associated with risk. Analyses exclude the first 5 years of follow-up, and adjust for study, sex, age at risk (in 5-year groups), and baseline smoking status. For analyses restricted to those who had never smoked, see webappendix p 17.
*
HR 0·37 (95% CI 0·30–0·44) in the range 15–25 kg/m2 after exclusion of the first 15 years of follow-up (leaving 956 deaths).
†
Includes 4113 deaths from cancer of unspecified site.