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. Author manuscript; available in PMC: 2009 Dec 11.
Published in final edited form as: J Med Chem. 2008 Dec 11;51(23):7352–7355. doi: 10.1021/jm801146d

Figure 6.

Figure 6

Functional antagonism of Smac mimetics against XIAP BIR3 in a cell-free functional assay. Addition of dATP and cyctochrome c into the MDA-MB-231 cell lysates induced activation of caspase-3/-7 and XIAP BIR3 at 500 nM completely inhibited the caspase-3/-7 activity. Compounds 1, 5, 6, 7 and 8 dose-dependently recovered the caspase activity.