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. Author manuscript; available in PMC: 2009 Mar 30.
Published in final edited form as: Arthritis Rheum. 2007 Dec;56(12):4024–4037. doi: 10.1002/art.23128

Figure 6. Bone erosion is arrested with anti-TNF therapy and correlates with sustained synovial inflammation during TNF-induced arthritis.

Figure 6

The change in cortical bone volume determined from the baseline and 8 week micro-CT scans for the anti-TNF (gray bars) and placebo (black bars) treated mice is presented as the mean +/−SD for the patella and talus (A). While there was no significant difference in delta patellar bone volume between groups (p=0.14), anti-TNF treatment had a significant effect on talus bone loss vs. placebo (*p<0.02). The MRI synovial volume data from a representative placebo TNF-Tg mouse described in Figure 5 is graphed to demonstrate the area under the curve (AUC) measurement as a function of joint inflammation and time (B). This measurement was used to perform regression analyses of the change in patella volume vs. synovial AUC (C) of all eight mice in the study described in Figure 5. Erosion data from the representative placebo mouse in (B) are presented as micro-CT reconstructed images of the patella at baseline (D) and at 8 weeks (E) with histology (F); and of the talus at baseline (G) and 8 weeks (H) with histology (I boxed region).