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Direct ER/mGluR interactions may underlie estradiol-induced activation of mGluRs. (A) Co-immunoprecipitation of ERα with mGluR1a. (B) Antagonism of ERs with ICI 182,780 attenuate CREB phosphorylation following application of the group I mGluR agonist DHPG. (C) ICI 182,780 has no effect on CREB phosphorylation in cultures generated from male tissue, which lack the mGluR-mediated estrogen response (from (Micevych and Mermelstein, 2008)).
