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. Author manuscript; available in PMC: 2010 Feb 1.
Published in final edited form as: Brain Behav Immun. 2008 Oct 4;23(2):240–250. doi: 10.1016/j.bbi.2008.09.012

Figure 4. AV411 potentiates both morphine and oxycodone analgesia.

Figure 4

AV411 (7.5mg/kg; ■) significantly potentiated morphine (A and C: 4mg/kg) and oxycodone (B and D: 4mg/kg) analgesia compared to vehicle treated rats (□). The EC50 of morphine+vehicle dose response (30min after opioid administration) was 4.1mg/kg whilst AV411 co-administration reduced this significantly to 0.77mg/kg (P<0.0001). The EC50 of oxycodone+vehicle dose response was 2.6mg/kg whilst AV411 co-administration reduced this significantly to 0.78mg/kg (P<0.001). n=6/group.