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. 2009 Mar 9;119(4):1008–1018. doi: 10.1172/JCI36010

Figure 1. MuPAR marks a subset of HSPCs and preserves their pool size in the BM.

Figure 1

(A) Decreased steady-state counts of various HSPC populations in the BM of Plaur–/– compared with WT mice. *P < 0.05 versus WT (n = 4–9). (B) WT and Plaur–/– mice were transplanted with syngeneic WT or Plaur–/– BMCs after lethal irradiation. At 6 weeks after transplantation, peripheral blood counts in the recipient mice were fully normalized (not shown). Counting of the number of CFU-Cs in the BM revealed that the number of HSPCs was reduced in the BM of mice grafted with Plaur–/– BM. Consistent herewith, fewer CFU-Cs were detected in nontransplanted Plaur–/– mice (not shown). *P < 0.05 (n = 4). (C) Fewer lethally irradiated splenectomized WT mice survived when transplanted with 1 × 105 Plaur–/– BMCs compared with WT BMC transplantation. P < 0.05 versus WT, Cox regression analysis (n = 17).