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. 2009 Mar 9;119(4):1008–1018. doi: 10.1172/JCI36010

Figure 6. Loss of uPAR impairs long-term engraftment and multilineage repopulation.

Figure 6

(A–C) Serial transplantation assay showed a significantly reduced contribution of Plaur–/– Ly5.2+ donor cells to the hematopoietic system in secondary Ly5.1+ recipients. (A) Percentage of Ly5.2+ PBMCs in secondary Ly5.1+ recipient mice at 8 and 24 weeks after transplantation (Tx). (B) Number of CRUs per 5 × 105 BMMCs in secondary Ly5.1+ recipient mice at 24 weeks after transplantation. (C) Multilineage repopulation in secondary Ly5.1+ recipient mice at 24 weeks after transplantation, revealing the percentage of GFP+ neutrophils (Gr1CD11bhi; N), monocytes (Gr1CD11blo; M), B lymphocytes (B220+; B) and T lymphocytes (CD3e+; T). *P < 0.05 versus WT donor cells (n = 6–9).