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. 2009 Mar 16;119(4):886–898. doi: 10.1172/JCI37262

Figure 2. Deficiency in macrophage p38α MAPK increases lesional necrosis.

Figure 2

(A and B) Dot plot showing the aortic root lesion area (A) and the aortic root necrotic area (B) of individual p38afl/flApoe–/– (n = 9) and p38afl/flLysMCre+/–Apoe–/– mice (n = 10). Bars represent mean values. The difference in aortic root lesion area between groups was not significant (P = 0.462, Mann-Whitney U test). (C) Mean percent necrotic area relative to total lesion area for each group. (D) Representative images of aortic root cross sections from p38afl/flApoe–/– and p38afl/flLysMCre+/–Apoe–/– mice stained with H&E. Necrotic areas (nec) are indicated. (E) Images from D, enlarged to demonstrate how the necrotic area was defined for quantification in each section (p38afl/flApoe–/–, 19,018 μm2; p38afl/flLysMCre+/–Apoe–/–, 45,826 μm2). Red lines show the boundary of the developing necrotic core. **P < 0.01, Mann-Whitney U test. Scale bars: 50 μm.