Table 2.
Indices for fasting subjects studied in the open label trials before salsalate therapy (pre) and after 2‐week treatment (post) (mean ± SEM).
| Salsalate 4.5 (g/d) | Salsalate 3.0 (g/d) | |||||
|---|---|---|---|---|---|---|
| Pre | Post | p‐value | Pre | Post | p‐value | |
| Weight (kg) | 88.6 ± 8.3 | 88.4 ± 8.4 | 0.8 | 93.7 ± 7.2 | 94.2 ± 7.1 | 0.2 |
| HDL (mmol/L) | ‐‐1.2 ± 0.1 | 1.1 ± 0.1 | 0.01 | 1.1 ± 0.1 | 1.1 ± 0.1 | 0.6 |
| LDL (mmol/L) | ‐‐3.2 ± 0.5 | 3.0 ± 0.4 | 0.2 | 2.7 ± 0.3 | 2.9 ± 0.3 | 0.2 |
| SBP (mm Hg) | 135 ± 4 | 128 ± 5 | 0.2 | 135 ± 6 | 125 ± 7 | 0.1 |
| DBP (mm Hg) | ‐75 ± 2 | 71 ± 4 | 0.3 | 77 ± 4 | 71 ± 5 | 0.02 |
| AST (U/L) | ‐25 ± 3 | 24 ± 4 | 0.6 | 20 ± 2 | 20 ± 2 | 0.7 |
| ALT (U/L) | ‐21 ± 1 | 24 ± 2 | 0.2 | 26 ± 4 | 22 ± 3 | 0.01 |
| Cr (μmol/L) | ‐67 ± 5 | 77 ± 5 | 0.005 | 68 ± 6 | 72 ± 6 | 0.04 |
HDL and LDL mg/dL × 0.0259 = mmol/L; Cr = creatinine mg/dL × 88.4 =μmol/L.