Table 2.
Risk of Squamous Cell Cervical Cancer Associated with HLA class I A, B, and Cw alleles
| Controls (N=504) |
Cases (n=490) |
||||||
|---|---|---|---|---|---|---|---|
| n | % | n | % | OR1 | 95% CI | Holm p-value2 |
|
| A*0101 | 154 | (30.6) | 143 | (29.2) | 1.0 | (0.8-1.3) | |
| A*0201 | 249 | (49.4) | 213 | (43.5) | 0.8 | (0.6-1.1) | |
| A*0301 | 120 | (23.8) | 143 | (29.2) | 1.4 | (1.1-1.9) | 0.02 |
| A*1101 | 60 | (11.9) | 59 | (12.0) | 1.0 | (0.7-1.5) | |
| A*2402 | 76 | (15.1) | 90 | (18.4) | 1.2 | (0.8-1.7) | |
| A*2902 | 40 | (7.9) | 27 | (5.5) | 0.7 | (0.4-1.1) | |
| A*3201 | 31 | (6.2) | 40 | (8.2) | 1.5 | (0.9-2.4) | |
| A*6801 | 28 | (5.6) | 25 | (5.1) | 0.9 | (0.5-1.6) | |
| B*0702 | 127 | (25.2) | 140 | (28.6) | 1.2 | (0.9-1.6) | |
| B*0801 | 124 | (24.6) | 89 | (18.2) | 0.7 | (0.5-1.0) | 0.15 |
| B*1501 | 57 | (11.3) | 31 | (6.3) | 0.6 | (0.4-0.9) | 0.02 |
| B*1801 | 38 | (7.5) | 29 | (5.9) | 0.8 | (0.5-1.3) | |
| B*2705 | 43 | (8.5) | 28 | (5.7) | 0.7 | (0.4-1.1) | |
| B*3501 | 54 | (10.7) | 46 | (9.4) | 0.8 | (0.5-1.3) | |
| B*4001 | 58 | (11.5) | 61 | (12.4) | 1.1 | (0.8-1.7) | |
| B*4402 | 70 | (13.9) | 112 | (22.9) | 1.9 | (1.4-2.7) | 0.0001 |
| B*4403 | 49 | (9.7) | 44 | (9.0) | 0.9 | (0.6-1.4) | |
| B*5101 | 48 | (9.5) | 53 | (10.8) | 1.1 | (0.7-1.7) | |
| B*5701 | 38 | (7.5) | 37 | (7.6) | 1.1 | (0.7-1.7) | |
| Cw*0102 | 34 | (6.7) | 37 | (7.6) | 1.0 | (0.6-1.7) | |
| Cw*0202 | 46 | (9.1) | 32 | (6.5) | 0.7 | (0.4-1.2) | |
| Cw*0303 | 43 | (8.5) | 42 | (8.6) | 1.1 | (0.7-1.7) | |
| Cw*0304 | 83 | (16.5) | 74 | (15.1) | 0.9 | (0.7-1.3) | |
| Cw*0401 | 92 | (18.3) | 82 | (16.7) | 0.9 | (0.6-1.2) | |
| Cw*0501 | 72 | (14.3) | 100 | (20.4) | 1.6 | (1.2-2.3) | 0.005 |
| Cw*0602 | 94 | (18.7) | 85 | (17.3) | 1.0 | (0.7-1.3) | |
| Cw*0701 | 152 | (30.2) | 116 | (23.7) | 0.8 | (0.6-1.0) | |
| Cw*0702 | 139 | (27.6) | 152 | (31.0) | 1.2 | (0.9-1.5) | |
| Cw*0704 | 13 | (2.6) | 26 | (5.3) | 2.1 | (1.0-4.1) | 0.07 |
| Cw*0802 | 34 | (6.7) | 30 | (6.1) | 0.9 | (0.6-1.5) | |
| Cw*1203 | 34 | (6.7) | 23 | (4.7) | 0.7 | (0.4-1.2) | |
| Cw*1502 | 16 | (3.2) | 27 | (5.5) | 1.6 | (0.8-3.0) | |
| Cw*1601 | 42 | (8.3) | 30 | (6.1) | 0.7 | (0.4-1.1) | |
1
Odds ratios are adjusted for race. Bolding represents significant associations, although rounding sometime caused confidence intervals to include 1.0.
2
The Holm p value corrects the Wald p value for multiple comparisons and was based on all alleles at a locus and is only shown for alleles with significant odds ratios.