Table 3.
Risk of Squamous Cell Cervical Cancer Associated with HLA class II DRB1 and DQB1 alleles
| Controls (N=538) |
Cases (n=538) |
||||||
|---|---|---|---|---|---|---|---|
| n | % | n | % | OR1 | 95% CI | Holm P value2 |
|
| DRB1*0101 | 79 | (14.7) | 80 | (14.9) | 1.1 | (0.8-1.5) | |
| DRB1*0301 | 135 | (25.3) | 100 | (18.6) | 0.7 | (0.5-1.0) | 0.08 |
| DRB1*0401 | 100 | (18.6) | 121 | (22.5) | 1.4 | (1.0-1.8) | 0.22 |
| DRB1*0404 | 48 | (8.9) | 39 | (7.2) | 0.8 | (0.5-1.3) | |
| DRB1*0701 | 139 | (25.8) | 132 | (24.5) | 1.0 | (0.7-1.3) | |
| DRB1*0801 | 30 | (5.6) | 25 | (4.6) | 0.9 | (0.5-1.5) | |
| DRB1*1101 | 33 | (6.1) | 65 | (12.1) | 2.1 | (1.3-3.2) | 0.001 |
| DRB1*1301 | 59 | (11.0) | 40 | (7.4) | 0.7 | (0.4-1.0) | |
| DRB1*1302 | 49 | (9.1) | 28 | (5.2) | 0.5 | (0.3-0.9) | 0.03 |
| DRB1*1401 | 25 | (4.6) | 28 | (5.2) | 1.1 | (0.6-1.9) | |
| DRB1*1501 | 143 | (26.6) | 147 | (27.3) | 1.1 | (0.8-1.4) | |
| DQB1*02 | 225 | (41.8) | 183 | (34.0) | 0.7 | (0.6-1.0) | 0.04 |
| DQB1*02013 | 135 | (25.1) | 100 | (18.6) | 0.7 | (0.5-1.0) | 0.08 |
| DQB1*02023 | 101 | (18.8) | 87 | (16.2) | 0.9 | (0.6-1.2) | |
| DQB1*0301 | 169 | (31.4) | 216 | (40.1) | 1.5 | (1.1-1.9) | 0.003 |
| DQB1*0302 | 119 | (22.1) | 111 | (20.6) | 0.9 | (0.7-1.2) | |
| DQB1*0303 | 55 | (10.2) | 64 | (11.9) | 1.2 | (0.8-1.7) | |
| DQB1*0402 | 23 | (4.3) | 28 | (5.2) | 1.1 | (0.6-1.9) | |
| DQB1*0501 | 100 | (18.6) | 106 | (19.7) | 1.1 | (0.8-1.5) | |
| DQB1*0503 | 23 | (4.3) | 28 | (5.2) | 1.2 | (0.7-2.1) | |
| DQB1*0602 | 146 | (27.1) | 147 | (27.3) | 1.0 | (0.8-1.4) | |
| DQB1*0603 | 61 | (11.3) | 43 | (8.0) | 0.7 | (0.5-1.0) | |
| DQB1*0604 | 35 | (6.5) | 21 | (3.9) | 0.6 | (0.3-1.0) | |
1
Odds ratios are adjusted for race. Bolding represents significant associations, although rounding sometimes caused confidence intervals to include 1.0.
2
The Holm p value corrects the Wald p value for multiple comparisons and was based on all alleles at a locus and is only shown for alleles with significant odds ratios.
3
DQB1*02 could not be discerned as *0201 versus *0202 by the assay; see the Methods section.