Table 4.
Significant risks of SCC associated with class I and II multilocus genotypes
| Loci | Alleles | Controls (N=502) |
Cases (N=490) |
||||
|---|---|---|---|---|---|---|---|
| n | % | n | % | OR1 | 95% CI | ||
| A-B-Cw-DRB1-DQB1 | 0201-4402-0501-0401-0301 | 18 | (3.6) | 32 | (6.5) | 2.0 | (1.1-3.7) |
| A-B-Cw-DRB1 | 0201-4402-0501-0401-xxxx | 20 | (4.0) | 36 | (7.4) | 2.1 | (1.2-3.6) |
| A-B-Cw-DQB1 | 0201-4402-0501-xxxx -0301 | 23 | (4.6) | 41 | (8.4) | 2.0 | (1.2-3.3) |
| A-B-DRB1-DQB1 | 0201-4402-xxxx-0401-0301 | 20 | (4.0) | 34 | (6.9) | 1.9 | (1.1-3.4) |
| B-Cw-DRB1-DQB1 | xxxx -4402-0501-0401-0301 | 22 | (4.4) | 42 | (8.6) | 2.2 | (1.3-3.7) |
| A-B-Cw | 0201-4402-0501-xxxx-xxxx | 43 | (8.6) | 59 | (12.0) | 1.5 | (1.0-2.3) |
| A-B-DQB1 | 0201-4402-xxxx-xxxx-0301 | 27 | (5.4) | 50 | (10.2) | 2.1 | (1.3-3.4) |
| A-B-DRB1 | 0201-4402-xxxx-0401-xxxx | 22 | (4.4) | 38 | (7.8) | 2.0 | (1.2-3.4) |
| A-Cw-DQB1 | 0201-xxxx -0501-xxxx-0301 | 23 | (4.6) | 44 | (9.0) | 2.1 | (1.3-3.6) |
| A-Cw-DRB1 | 0201-xxxx-0501-0401-xxxx | 20 | (4.0) | 37 | (7.6) | 2.1 | (1.2-3.7) |
| A-DRB1-DQB1 | 0201-xxxx-xxxx-0401-0301 | 30 | (6.0) | 54 | (11.0) | 2.1 | (1.3-3.3)* |
| B-Cw-DQB1 | xxxx- 4402-0501-xxxx-0301 | 30 | (6.0) | 59 | (12.0) | 2.2 | (1.4-3.6)* |
| B-Cw-DRB1 | 4402-0501-0401 | 25 | (5.0) | 49 | (10.0) | 2.3 | (1.4-3.8)* |
| B-DRB1-DQB1 | 4402-0401-0301 | 24 | (4.8) | 45 | (9.2) | 2.1 | (1.3-3.6) |
| Cw-DRB1-DQB1 | 0501-0401-0301 | 22 | (4.4) | 43 | (8.8) | 2.2 | (1.3-3.8) |
| A-B | 0201-4402 | 51 | (10.2) | 71 | (14.5) | 1.6 | (1.1-2.3) |
| A-DQB1 | 0201-0301 | 74 | (14.7) | 108 | (22.0) | 1.7 | (1.2-2.3)* |
| B-Cw | 4402-0501 | 58 | (11.6) | 90 | (18.4) | 1.8 | (1.3-2.6)* |
| B-DQB1 | 4402-0301 | 35 | (7.0) | 73 | (14.9) | 2.4 | (1.6-3.7)* |
| B-DRB1 | 4402-0401 | 27 | (5.4) | 52 | (10.6) | 2.3 | (1.4-3.7)* |
| Cw-DQB1 | 0501-0301 | 35 | (7.0) | 64 | (13.1) | 2.1 | (1.4-3.2)* |
| Cw-DRB1 | 0501-0401 | 25 | (5.0) | 52 | (10.6) | 2.4 | (1.5-4.0)* |
| DRB1-DQB1 | 0401-0301 | 55 | (10.2) | 81 | (15.1) | 1.7 | (1.1-2.4) |
| B-DRB1-DQB1 | 4402-1101-0301 | 3 | (0.6) | 28 | (5.7) | 10.0 | (3.0-33.3*) |
| B-DRB1 | 4402-1101 | 3 | (0.6) | 29 | (5.9) | 10.5 | (3.2-34.8)* |
| DRB1-DQB1 | 1101-0301 | 30 | (5.6) | 64 | (11.9) | 2.3 | (1.4-3.6)* |
| B-Cw-DQB1 | 0702-0702-0301 | 24 | (4.8) | 53 | (10.8) | 2.5 | (1.5-4.2)* |
| B-DQB1 | 0702-0301 | 24 | (4.8) | 58 | (11.8) | 2.8 | (1.7-4.5)* |
| Cw-DQB1 | 0702-0301 | 28 | (5.6) | 59 | (12.0) | 2.3 | (1.4-3.7)* |
| A-DQB1 | 0301-0501 | 28 | (5.6) | 42 | (8.6) | 1.7 | (1.0-2.8) |
| A-B | 0201-1501 | 43 | (8.6) | 16 | (3.3) | 0.4 | (0.2-0.7)* |
| A-Cw | 1101-0401 | 31 | (6.2) | 16 | (3.3) | 0.5 | (0.3-1.0) |
| A-DQB1 | 0201-0201 | 54 | (10.8) | 27 | (5.5) | 0.5 | (0.3-0.8)* |
| B-Cw | 0801-0701 | 122 | (24.3) | 84 | (17.1) | 0.7 | (0.5-0.9) |
| Cw-DQB1 | 0701-02 | 110 | (21.9) | 76 | (15.5) | 0.7 | (0.5-1.0) |
| DRB1-DQB1 | 0301-02 | 136 | (25.3) | 100 | (18.6) | 0.7 | (0.5-1.0) |
1
Odds ratios are adjusted for race. Bolding represents significant associations, although rounding sometimes caused confidence intervals to include 1.0.
*
Holm test p-value < 0.05, result is significant after adjusting for multiple comparisons.